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Read what researchers wanted to find out and what it means in everyday words. Open the details if you want to see how a study was done. The product pages have a shorter explanation.

Original sources checked on 4 October 2026. AI-assisted editorial summaries, not a systematic review or an independent medical assessment.

Showing research linked to NAD+.

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2 studies found

Research context

What happens to NAD+ during an infusion

11 men: 8 received NAD+ and 3 saline

What did they want to find out?

Where does NAD+ appear after an infusion?

What did researchers observe?

NAD+ and related products were measured in blood and urine over eight hours.

What does this mean for you?

Tracking molecules explains processing; it does not demonstrate feeling better.

What we still do not know

No everyday-energy, memory or lifespan outcome; no brain uptake or long-term safety measurement.

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Original sources checked on 4 October 2026. AI-assisted editorial summaries, not a systematic review or an independent medical assessment.

What happens to NAD+ during an infusion

Frontiers in Aging Neuroscience · 2019

How it was studied

Pilot with a saline-control group. 11 men: 8 received NAD+ and 3 saline.

Study finding

NAD+ and related products were measured in blood and urine over eight hours.

Study limitations

No everyday-energy, memory or lifespan outcome; no brain uptake or long-term safety measurement.

Who is behind the study?

Identified authors
Ross Grant, Jade Berg, Richard Mestayer, Nady Braidy, James Bennett, Susan Broom, James Watson
Funding and involvement
NAD+ Research Inc. and Australasian Research Institute; Archway donated NAD+.
Disclosed interests and verification limits
Mestayer was NAD+ Research director and Springfield medical director; Broom received consulting fees.

Terms explained

Plasma
The liquid part of blood.
Metabolite
A product formed when a substance is transformed.

Read the source and its limitations. A reference does not automatically validate a commercial product.

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Research context

Tolerability of NAD+ and NR infusions

6 NAD+ clients and 8 NR clients; 30-day follow-up

What did they want to find out?

How did clients feel during the infusions?

What did researchers observe?

All six NAD+ clients reported moderate or severe symptoms during infusions.

What does this mean for you?

No documented 'adverse events' does not mean there was no discomfort.

What we still do not know

No random allocation or placebo; NR is not NAD+. Text and a figure caption disagree about ALP.

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Original sources checked on 4 October 2026. AI-assisted editorial summaries, not a systematic review or an independent medical assessment.

Tolerability of NAD+ and NR infusions

Frontiers in Aging · 2026

How it was studied

Retrospective commercial-record review. 6 NAD+ clients and 8 NR clients; 30-day follow-up.

Study finding

All six NAD+ clients reported moderate or severe symptoms during infusions.

Study limitations

No random allocation or placebo; NR is not NAD+. Text and a figure caption disagree about ALP.

Who is behind the study?

Identified authors
Kirsten Reyna, Greer Heinzen, Nikita Patel, Marie Ritter, Alexandra Siojo, Henry Legere, Rachele Pojednic
Funding and involvement
Restore Hyper Wellness; Niagen Biosciences donated NR.
Disclosed interests and verification limits
All seven authors disclosed Restore employment. Corporate involvement was not independently verified.

Terms explained

Retrospective
A study of records that already existed.
Precursor
A substance the body can use to make another.

Read the source and its limitations. A reference does not automatically validate a commercial product.

Read the source